Iloprost, a synthetic prostacyclin analog used as vasodilator to kohdella pulmonary arterial hypertension (PAH), has been approved by the U.S. ruoka and Drug Administration for treatment of severe frostbite. This is first approved lääkitys in the USA to treat severe frostbite in adults to reduce the risk of amputation.
Frostbite is a serious condition that require immediate lääketieteellinen attention. It is caused due to exposure to freezing temperature long enough to allow ice crystals to form in the tissues. People working outdoors in cold regions such as security personals, industrial workers, mountaineers or hikers etc are usually affected by frostbite. Amputation of fingers and toes because of frostbite is common in such regions despite advances in terveys hoitopalvelut.
Iloprost on synteettinen prostatykliinianalogi. Se kumoaa verisuonten supistumisen ja estää verihiutaleiden aktivaatiota, toimii verisuonia laajentavana, avaa verisuonia ja estää veren hyytymistä. Se hyväksyttiin ensimmäisen kerran vuonna 2004 keuhkoverenpainetaudin (PAH) hoitoon.
Iloprost and thrombolytics are beneficial for treating frostbite. In Canada, potilaat with severe frostbite involving freezing of skin and underlying tissues and stoppage of blood flow have been successfully treated with iloprost. The old drug has now been approved by the U.S. Food and Drug Administration (FDA) vakavien paleltumien hoitoon.
- FDA granted the approval to Eicos Sciences Inc. to manufacture iloprost for treatment of severe frostbite by the brandname “Aurlumyn”.
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Viitteet:
- FDA Approves First Medication to Treat Severe Frostbite. Posted on 14 February 2024. Available at https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite/
- Regli, IB, Oberhammer, R., Zafren, K. et ai. Paleltumahoito: järjestelmällinen katsaus meta-analyyseillä. Scand J Trauma Resusc Emerg Med 31, 96 (2023). https://doi.org/10.1186/s13049-023-01160-3
- Poole A. ja Gauthier J. 2016. Vakavan paleltumien hoito iloprostilla Pohjois-Kanadassa. CMAJ 06. joulukuuta 2016 188 (17-18) 1255-1258; DOI: https://doi.org/10.1503/cmaj.151252
- Gruber, E., Oberhammer, R., Brugger, H. et ai. Pitkittynyt kriittinen lumivyöryhautaus lähes 23 tuntia, vakava hypotermia ja vakava paleltuma sekä hyvä toipuminen: tapausraportti. Scand J Trauma Resusc Emerg Med 32, 11 (2024). https://doi.org/10.1186/s13049-024-01184-3
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